Ochratoxin

Ochratoxin-A Molecular Structure

Ochratoxin Tech Sheet for Practitioners is included in CME Course Materials

Ochratoxin Facts for Patients

Ochratoxin is one of the most prevalent mycotoxins in water-damaged buildings and food.
It’s been implicated in numerous health conditions, including many that affect the kidneys.

It binds to and lowers albumin, which affects how it’s detoxified. It also reduces zinc stores inside cells.

Ochratoxin can reduce immune function, inhibit energy production, and is neurotoxic especially to males. Studies have correlated Ochratoxin exposure to birth defects and the male prevalence of autism.

Mold Sources

Aspergillus ochraseus, Aspergillus niger, Penicillium verrucosum, Penicillium nordicum, and Penicillium chrysogenum
Color – arious species of mold can take on any color, even “black mold” color
Favorite building material – flooring, carpet, ceiling tiles, heating ducts

Signs

LABS ~ Low albumin, reduced or lowering GFR (glomerlular filtration rate)

Symptoms

Fatigue
Brain fog
Headache, migraine
Low appetite or nausea
Chemical sensitivity
Itchy skin
Frequent urination, which may over time become low urine output from low kidney function
Edema
High blood pressure
Chest pain
Muscle weakness and/or cramps
Exercise intolerance
Frequent infections

Things That Help My Patients

Therapeutic Diet ~

  • Eat the rainbow of colorful vegetables, 5-7 servings daily.
  • Plenty of good fats every day.
  • 2 Tbsp ground organic seeds as insoluble fiber binder.
  • Flavor with rosemary, mint, sage, and thyme. (Ochratoxin-specific mycotoxin neutralizing activity)

Bioflavonoids unbind Ochratoxin from albumin, which reduces its toxic effects on the kidneys.
Bioflavonoids require frequent, repeated dosing for this effect.
A mixed bioflavonoid supplement is ideal as it covers the wide range of the flavonoids studied.
*Focus on astaxanthin, luteolin, quercetin, lycopene for Ochratoxin-specific activity.

Zinc. (Take with food. May cause nausea on empty stomach.)

Resveratrol. For kidneys.

Tocotrienols. Improves blood pressure, restores GFR, protects kidneys.

Rosemary (Rosmarinus officinalis). Rosmarinic acid has a significant cell protective effect against Ochratoxin and is antifungal.

Glutathione. Or use glutathione inducers if not tolerated – ALA, NAC, Selenium.
NAC+Selenomethionine – combination combats immunotoxic effects.

Milk Thistle. Potent protective effect against Ochratoxin. Reduces immunotoxicity.

Spore-based probiotic. Bacillus spp. 1 capsule yielding multi-billion CFUs.
*Start with sprinkles* using 1 capsule over 2 weeks time for first introduction as it can cause severe die-off symptoms at full dose initially.

Melatonin. Take at dinnertime to avoid morning grogginess. Kidney protective. Ushers zinc into cells.

REFERENCES

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Allegra A, Tonacci A, Pioggia G, Musolino C, Gangemi S. Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials. Nutrients. 2020 Jun 10;12(6):1739. doi: 10.3390/nu12061739. PMID: 32532056; PMCID: PMC7352773.

Cui G, Li L, Xu W, Wang M, Jiao D, Yao B, Xu K, Chen Y, Yang S, Long M, Li P, Guo Y. Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway. Oxid Med Cell Longev. 2020 Mar 4;2020:7639109. doi: 10.1155/2020/7639109. PMID: 32190177; PMCID: PMC7073479.

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Xu W, Wang M, Cui G, Li L, Jiao D, Yao B, Xu K, Chen Y, Long M, Yang S, He J. Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway. Toxins (Basel). 2019 Sep 17;11(9):540. doi: 10.3390/toxins11090540. PMID: 31533259; PMCID: PMC6784241.

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